|
KMID : 0371320000590030313
|
|
Journal of the Korean Surgical Society
2000 Volume.59 No. 3 p.313 ~ p.320
|
|
|
Correlation between Tumor Response to Neoadjuvant Chemotherapy and Patient Outcome in Breast Cancer
|
|
김제룡/Je-Ryong Kim
박혜덕/장일성/Hye-Duck Park/Eil-Sung Chang
|
|
|
Abstract
|
|
|
Purpose: Neoadjuvant chemotherapy is being used increasingly in the treatment of patients with large or locally advanced breast cancer with the aims of downstaging and eliminating micrometastasis. We report a correlation between tumor response to
preoperative primary chemotherapy and patient outcome in a series of 73 consecutive patients with breast cancer. Methods: From Feb. 1991 to Oct. 1998, 73 patients with breast cancer (tumor size＞3 cm or clinically axillary node positive) were
treated
with multimodality therapy, including a sandwich type of chemotherapy, comprised of 3 preoperative cycles and 3 postoperative 3 cycles of FEC or MMM. The median follow-up period was 53 months. Results: The overall objective clinical response rate
(complete & partial response) of the primary tumor to chemotherapy was 75.5% (standard UICC criteria). The pathologic complete response rate was 9.6%. The overall 5-year survival rate was 86.8%, and the overall 5-year disease free survival rate
was
82.6%. The response rate to chemotherapy declined with increasing tumor size, but there was no relationship between the clinical response to chemotherapy and menopausal status, chemotherapeutic regimen, or histopathologic type. A
breast-conserving
operation could be done in 64.4% of the patients as a result of a decrease in the tumor size. Conclusion: Neoadjuvant chemotherapy allows a breast-conserving operation to be performed more frequently in cases of large or locally advanced breast
cancer.
The responses to neoadjuvant chemotherapy is a powerful prognostic factor for the overall survival and the disease free survival in breast cancer patients.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|